NextCure presents Phase 1b data on NC410 and pembrolizumab combo at ASCO

NextCure protein, in combination with pembrolizumab will be presented at the American Society of Clinical Oncology ASCO Annual Meeting in Chicago. The trial evaluated the combination in immune checkpoint inhibitor ICI naive and refractory microsatellite stable, MSS/microsatellite instability-low , MSI-L, colorectal cancer CRC and ovarian cancer and demonstrated clinical activity in these hard-to-treat cancers. The data will be presented in a poster session by clinical trial investigator Eric S. Christenson, M.D., Assistant Professor of Oncology at Johns Hopkins Sidney Kimmel Comprehensive Cancer Center.”While MSS/MSI-L CRC and ovarian cancer are difficult to treat and recalcitrant to immunotherapy, the combination of NC410 and pembrolizumab demonstrated clinical activity against both tumor types. MSS/MSI-L CRC study subjects who achieved clinical benefit of partial responses or stable disease by the first scan at 9 weeks maintained continued disease control with a median duration of 5.5 months, which is clinically meaningful for this patient population,” said Michael Richman NextCure’s President and chief executive officer. “In addition, biomarker data support the proposed mechanism of action of NC410 in remodeling the ECM, enhancing infiltration and activation of immune cells in the TME. While the focus of the current presentation is on the targeted CRC patient population, we look forward to reporting the results from the ongoing ovarian cancer cohort expansion later this year.”