Morning Movers: Metsera surges, Pfizer gains after acquisition pact

Stock futures are slipping slightly after last week’s strong gains, as investors weigh a mix of policy signals, corporate risks, and regulatory surprises. The markets begin the day with modest tension, carrying lingering optimism from recent rallies but also a growing sense of caution. One of the more immediate concerns dragging sentiment is the Trump administration’s announcement of a new fee for H-1B visas which has tech firms worrying about labor-cost headwinds.

Gold is holding strong, having climbed to fresh highs with spot prices exceeding $3,720 per ounce, propelled by expectations of further Fed easing and perceived economic softness. Silver is also rising, marking its strongest levels in over a decade. Oil is under pressure from ample supply, soft demand signals and mixed global developments.

In pre-market trading, S&P 500 futures fell 0.27%, Nasdaq futures fell 0.25% and Dow futures fell 0.42%.

Check out this morning’s top movers from around Wall Street, compiled by The Fly, and subscribe to the Fly By on YouTube.

HIGHER –

• MBX Biosciences (MBX) up 136% after once-weekly canvuparatide achieved the primary endpoint with statistical significance at Week 12 in its Phase 2 Avail trial
• Metsera (MTSR) and Pfizer (PFE) up 61% and 1%, respectively, after Pfizer and the company entered into a definitive agreement under which Pfizer will acquire Metsera for $47.50 per share in cash
• Anywhere Real Estate (HOUS) up 57% after Compass (COMP) and the company jointly announced the signing of a definitive merger agreement to combine in an all-stock transaction
• ODP Corporation (ODP) up 32% after entering into a definitive agreement to be acquired by an affiliate of Atlas Holdings for $28 per share in cash
• Ionis Pharmaceuticals (IONS) up 1% after zilganersen 50 mg demonstrated statistically significant and clinically meaningful stabilization on the primary endpoint of gait speed

LOWER –

• Quantum Computing (QUBT) down 13% after entering into securities purchase agreements with institutional investors for the purchase and sale of 26,867,276 shares of common stock in an oversubscribed private placement priced at the market
• Compass (COMP) down 11% after the company and Anywhere Real Estate jointly announced the signing of a definitive merger agreement to combine in an all-stock transaction
• Amer Sports (AS) down 3% after Bloomberg reported Chinese authorities launched an investigation after a fireworks show in Tibet sponsored by Amer Sports’ Arc’teryx sparked a backlash on social media
• T-Mobile (TMUS) down 1% after announcing that it has named current COO Srini Gopalan as T-Mobile’s next CEO