MIRA says it achieves 100% reversal of neuropathic pain with oral Ketamir-2

MIRA Pharmaceuticals announced a major breakthrough in the treatment of neuropathic pain. A recent pre-clinical study in rats demonstrated that its novel oral ketamine analog, Ketamir-2, produced a significant reversal of neuropathic pain, induced by nerve ligation, culminating in a 100% normalization of pain thresholds at the highest dose. This effect stands in stark contrast to traditional ketamine, which proved ineffective orally under the same experimental conditions. The study, conducted at Pharmaseed Ltd, utilized a nerve ligation model to replicate human neuropathic pain and specifically investigates mechanical allodynia. The results were compelling: low oral doses of Ketamir-2 led to a significant reversal of pain for 14 and 22 days following the operation. At higher oral dose, Ketamir-2 achieved complete normalization of the pain threshold, representing a 100% reversal of the neuropathic pain signal. These outcomes underscore Ketamir-2’s superior efficacy and highlight its potential as a transformative treatment for neuropathic pain, especially compared to oral ketamine, which did not deliver significant pain relief. In light of this compelling data, MIRA Pharmaceuticals is conducting additional studies to evaluate Ketamir-2’s efficacy in treating cancer-induced depression and neuropathic pain. These studies aim to explore cancer-related indications, which could pave the way for faster regulatory approvals and innovative clinical study designs. MIRA is optimistic that these efforts could demonstrate efficacy in humans as early as 2025. MIRA Pharmaceuticals continues to advance its research, focusing on scaling production and preparing for the next stages of clinical trials. The company remains committed to bringing safer and more effective treatments to market, with Ketamir-2 at the forefront of its pipeline.