Intellia commercial position in question after safety event. says Goldman

Goldman Sachs believes the grade 4 liver transaminase elevation safety event disclosed by Intellia Therapeutics (NTLA) for the Phase 3 MAGNITUDE study potentially places nex-z’s commercial positioning further in question given the CRISPR therapy’s lack of an established long-term safety profile. The therapy has shown limited differentiation on efficacy versus siRNA competitors, the analyst tells investors in a research note. Goldman has a Sell rating on Intellia with an $8 price target The stock in morning trading is down 28%, or $2.70, to $6.96.