Harmony Biosciences (HRMY) announced dosing of the first participant in a Phase 1 clinical trial of BP1.15205, an investigational orexin 2 receptor agonist being developed for the treatment of narcolepsy, idiopathic hypersomnia and other central disorders of hypersomnolence. The Phase 1 clinical trial will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of BP1.15205 after single and multiple ascending doses in healthy volunteers and sleep-deprived healthy subjects. Topline data are expected in 2026.
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