Cognition publishes Phase 2 results on Zervimesine

Cognition Therapeutics (CGTX) announced that a manuscript entitled, “Phase 2 Study of Zervimesine in Participants with Mild-to-Moderate Dementia with Lewy Bodies” has been published in the journal, Alzheimer’s & Dementia, the journal of the Alzheimer’s Association. Results from this study were first presented in January 2025 at the International Lewy Body Dementia Conference in Amsterdam. “The Phase 2 SHIMMER study, our first in DLB, met its primary goal of confirming zervimesine’s safety and tolerability,” explained Anthony Caggiano, Cognition’s chief medical officer. “Importantly, zervimesine was also shown to have a favorable impact on behavioral, cognitive, functional, and movement domains, many of which are core clinical features of DLB. There are currently no approved disease-modifying treatments for DLB, highlighting the unmet need for novel therapies.”