Celularity announces publication highlighting potential of CYNK-001

Celularity (CELU) announced a publication in the April 4 issue of peer-reviewed journal Frontiers in Immunology, the official journal of the International Union of Immunological Societies. In “Senescence, NK cells, and cancer: navigating the crossroads of aging and disease,” Celularity scientists discuss how aging may influence the battle between the immune system and cancer, and the implications of senoablative Natural Killer, or NK, cells in disease progression. They emphasize that “preserving the function of NK cells during aging is essential for promoting healthy aging and longevity.” They conclude the publication by discussing the potential of adoptive NK cell therapy as a countermeasure to age-related decline in immunological function, a condition called immunosenescence. Robert Hariri, publication coauthor and Celularity Chairman and CEO, observed, “NK cell-based therapies demonstrate promise not only in treating cancer and viral infections but also a key role in rejuvenating the aging immune system, by eliminating senescent cells. This process, which we term “senoablation,” kills and clears senescent cells that exhibit a senescence-associated secretory phenotype, releasing toxic cytokines that promote inflammation and malignant transformation. Aside from the release of these toxic cytokines, senescent cells that remain in tissues block functional regeneration by healthy normal cells. We believe that eliminating these senescent cells could mitigate some of the negative effects of aging and offer clinical benefits in conditions such as age-related frailty and sarcopenia. Our clinical-stage, placental-derived allogeneic NK cell investigational candidate, CYNK-001, has been studied in over 70 subjects with acceptable safety and may represent a promising approach to addressing a range of conditions driven by cellular senescence.”