Castle Biosciences announces publication of papers on DecisionDx-Melanoma test

Castle Biosciences (CSTL) announced the recent publication of two papers in the World Journal of Surgical Oncology and Cancer Medicine sharing reports from the prospective, multicenter DECIDE study demonstrating the significant impact of the Company’s DecisionDx-Melanoma test on SLNB decision-making for patients with melanoma. The initial report from DECIDE, published in 2023, showed that DecisionDx-Melanoma test results influenced 85% of SLNB decisions, demonstrating the significant clinical value of the test to help guide risk-aligned patient care. The second report, recently published in the World Journal of Surgical Oncology, confirmed the performance of a low-risk DecisionDx-Melanoma result to predict SLN positivity rates of less than 5% in patients who elected to have an SLNB despite the test result. In the second report, no patient with a DecisionDx-Melanoma-predicted risk of SLN positivity of less than 5% who decided to have an SLNB procedure had a positive node. The third report, published in Cancer Medicine, shares outcomes of patients in the DECIDE study with a low-risk DecisionDx-Melanoma test result, of which approximately half decided to forgo an SLNB and 48.5% proceeded with an SLNB despite the DecisionDx-Melanoma test result. Of clinical significance, all patients with a low-risk Class 1A test result were recurrence free.