Cartesian Therapeutics (RNAC) announced positive initial data from its ongoing Phase 2 open-label trial of Descartes-08 in patients with systemic lupus erythematosus, or SLE. The company reported a 100% LLDAS response rate and a disease remission, or DORIS, response in two out of three patients who reached the month 3 follow-up. Descartes-08 was observed to have a favorable safety profile supporting outpatient administration. Cartesian also announced the expansion of clinical development for Descartes-08 into myositis and now plans to pause further development in SLE to prioritize opportunities in myasthenia gravis and myositis.
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