Capricor Therapeutics (CAPR) announced the publication in Biomedicines, an international peer-reviewed journal, describing a novel in-vitro potency assay designed to characterize the anti-fibrotic mechanism of action of the Capricor’s lead investigational product, Deramiocel, which is currently in late-stage development for the treatment of Duchenne muscular dystrophy, DMD. The publication, titled “A Novel In Vitro Potency Assay Demonstrating the Anti-Fibrotic Mechanism of Action of CDCs in Deramiocel,” showed results that further elucidate the biological activity of cardiosphere-derived cells, the active component of Deramiocel. The study found that CDCs, through their secreted exosomes and soluble factors, suppressed collagen I and III gene expression in primary human fibroblasts in vitro, supporting their potential to modulate fibrotic processes associated with disease progression.
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