Bionano announces French publication of method for analysis of MM by OGM

Bionano Genomics (BNGO) announced a study published in The Journal of Molecular Diagnostics that describes a method for analysis of multiple myeloma by optical genome mapping, OGM. Direct analysis of multiple myeloma, MM, samples, by methods such as FISH or OGM, can be problematic because it is challenging to isolate enough cells with a known MM marker on their surface, so-called CD138-positive cells. In this paper, researchers at Institute of Medical Genetics, Lille University Hospital, Lille, France, have described a method for OGM that can overcome the hurdle of limited sample quantity and can cut in half the effective CD138-positive cell requirement for analysis by OGM. Key Findings and Takeaways: Mixing CD138-positive with CD138-negative cells from the same sample at a ratio of 1:1 can be sufficient to perform OGM; OGM reveals More Genetic Events; OGM Streamlines the Analysis; OGM Improves Prognostic Risk Evaluation.