Athira Pharma presents results from Phase 1 trial of ATH-1105 at ALS Nexus

Athira Pharma (ATHA) presented results from its Phase 1 clinical trial of ATH-1105 in healthy volunteers at the ALS Nexus 2025 conference in Dallas, Texas. ALS Nexus convenes leading experts from the ALS community, including researchers, healthcare professionals, advocates and individuals living with amyotrophic lateral sclerosis, ALS, to connect and learn about advances in research, clinical care and advocacy. ATH-1105 is the Company’s novel, orally available, CNS-penetrant, next-generation small molecule drug candidate designed to positively modulate the neurotrophic HGF system for the potential treatment of neurodegenerative diseases, including ALS. Results from the Phase 1 trial of ATH-1105 demonstrated a favorable safety and tolerability profile as well as dose-proportional pharmacokinetics and CNS penetration. ATH-1105 has also demonstrated consistent and robust beneficial effects in preclinical models of ALS.