Applied Molecular "announced top-line Phase 2 results from the LOMBARD monotherapy trial for AMT-101 in biologic-naive and experienced patients with moderate-to-severe ulcerative colitis. AMT-101 is an investigational, once-daily, GI-selective, oral fusion of IL-10 and AMT’s proprietary carrier molecule. The clinical remission rate in patients treated with AMT-101 monotherapy was 17.1% compared to a CR rate of 20.0% with placebo, which was above the company’s baseline assumption for placebo CR rates based on published data in moderate-to-severe UC patients."
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