RBC Capital says Apnimed released the topline results from its SynAIRgy Phase III trial of AD109, which showed the prospective once-daily oral pill for obstructive sleep apnea met its primary endpoint, with a mean reduction in Apnea-Hypopnea Index 55.6% from baseline. Other secondary and exploratory endpoints included reducing sleep apnea disease severity in 51.2% of participants and 22.3% of participants achieved complete disease control, the analyst tells investors in a research note. RBC expects that successful commercialization of AD109 would likely have a negative impact on ResMed’s (RMD) addressable market as AD109 “could offer a less invasive, more user-friendly and viable alternative” to positive airway pressure therapy. The firm says ResMed “now has a number of competitive threats on the horizon,” including the return of Philips in the U.S. if it can satisfy the consent decree requirements as well as the impact of GLP-1s and of AD109. The firm has a Sector Perform rating on ResMed. The stock morning is down 2% to $248.98.
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