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Amylyx to discontinue ORION program of AMX0035

Amylyx (AMLX) announced the decision to discontinue the ORION program of AMX0035 in adults living with progressive supranuclear palsy. AMX0035 did not show differences compared to placebo on primary or secondary outcomes at Week 24. Based on these results, the company will discontinue the Phase 2b trial and open-label extension and will not initiate the Phase 3 portion of the program. Safety data were consistent with safety data from prior studies, and AMX0035 continued to be generally well-tolerated. Amylyx continues to expect its cash runway to extend through the end of 2026.

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