Andrew Fein, an analyst from H.C. Wainwright, maintained the Buy rating on Vertex Pharmaceuticals. The associated price target remains the same with $478.00.
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Andrew Fein has given his Buy rating due to a combination of factors that highlight Vertex Pharmaceuticals’ promising future in the renal disease market. The company’s kidney portfolio, particularly with drugs like povetacicept and inaxaplin, is showing significant potential to become a major growth driver, similar to its success in the cystic fibrosis sector. The RUBY-3 trial data has demonstrated impressive results in reducing proteinuria and resolving hematuria, along with biomarker validation, which are critical in treating IgAN and pMN. These outcomes suggest that Vertex’s renal programs could significantly impact the treatment landscape.
Furthermore, the rapid enrollment in the RAINIER trial indicates an accelerated timeline towards potential market entry by mid-2027. The clean safety profile of the treatments, along with the dual mechanism of povetacicept, positions it as a strong candidate in the competitive IgAN market. Despite challenges in the commercial landscape, the robust clinical data and strategic development of the renal franchise provide a solid foundation for future growth, justifying the Buy rating.
In another report released today, Citi also maintained a Buy rating on the stock with a $575.00 price target.

