Andrew Fein, an analyst from H.C. Wainwright, maintained the Buy rating on Amylyx Pharmaceuticals Inc (AMLX – Research Report). The associated price target remains the same with $16.00.
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Andrew Fein has given his Buy rating due to a combination of factors including the promising mechanism of action of Amylyx Pharmaceuticals’ AMX0114 in targeting Calpain for ALS treatment. The recent findings from Henrik Zetterberg’s lab highlight the role of Calpain in neurofilament light chain (NfL) degradation, which is crucial for understanding axonal degeneration in ALS. This aligns with the potential of AMX0114 to stabilize the NfL network in axons, potentially slowing disease progression.
Furthermore, the ongoing LUMINA trial, which is evaluating the pharmacokinetics and pharmacodynamics of AMX0114, shows promise with its multi-center, placebo-controlled design. The trial includes key biomarkers such as calpain-2 and NfL, which are critical for assessing the drug’s efficacy. Given these insights and the potential impact on ALS treatment, Fein’s Buy rating reflects optimism about the future success of AMX0114 in the market.
Based on the recent corporate insider activity of 34 insiders, corporate insider sentiment is negative on the stock. This means that over the past quarter there has been an increase of insiders selling their shares of AMLX in relation to earlier this year.