Jefferies analyst Clara Dong maintained a Buy rating on Olema Pharmaceuticals today and set a price target of $43.00.
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Clara Dong’s rating is based on the promising potential of Olema Pharmaceuticals’ oral SERD, palazestrant, in the treatment of breast cancer. The recent positive data from Roche’s Phase 3 trials with giredestrant, another oral SERD, has bolstered confidence in the efficacy of this class of drugs, particularly in early-stage ER+ breast cancer. This data suggests a significant reduction in the risk of invasive disease recurrence, which is a promising indicator for Olema’s own trials.
Dong notes that the strategic value of Olema’s wholly owned Phase 3 oral SERD is increasing, especially as the breast cancer market is largely comprised of ER+ patients. The upcoming data releases in 2026 are expected to further validate Olema’s position, with the potential to differentiate its product in a competitive landscape. The positive sentiment and strategic positioning make Olema an attractive investment opportunity, leading to the Buy rating.
Dong covers the Healthcare sector, focusing on stocks such as BeOne Medicines, Cogent Biosciences, and Kymera Therapeutics. According to TipRanks, Dong has an average return of 14.2% and a 60.00% success rate on recommended stocks.

