Zymeworks Sets 2026 Strategy on Zanidatamab Momentum, ADC Pipeline and Cash-Fueled Growth

Zymeworks ( (ZYME) ) has issued an update.

Zymeworks has outlined its strategic priorities for 2026 following what it describes as a transformative 2025 marked by positive late-stage clinical data, regulatory wins, and expanding collaborations. The company highlighted positive Phase 3 results for its partnered HER2-targeted antibody Ziihera (zanidatamab-hrii) in first-line HER2-positive gastroesophageal adenocarcinoma, alongside recent approvals of zanidatamab in China and Europe for biliary tract cancer, which together position the asset as a key future royalty and milestone driver with up to $440 million in potential regulatory payments tied to GEA approvals across major markets. Additional momentum came from partners such as J&J, which advanced pasritamig into multiple Phase 3 trials, and from internal programs including first-in-human studies of the GPC3-targeted ADC ZW251, encouraging early data for the folate receptor-alpha ADC ZW191 in gynecological cancers, and new preclinical progress in its bispecific respiratory program ZW1528 and solid tumor ADC and TriTCE platforms. Supported by approximately $270.6 million in year-end 2025 cash and securities, anticipated regulatory milestones, a newly authorized $125 million share repurchase program, and plans to pursue royalty growth, strategic acquisitions, and continued R&D, Zymeworks says it is positioned to extend its cash runway beyond 2028 and to compound long-term value for patients, partners, and shareholders.

The most recent analyst rating on (ZYME) stock is a Hold with a $23.00 price target. To see the full list of analyst forecasts on Zymeworks stock, see the ZYME Stock Forecast page.

Spark’s Take on ZYME Stock

According to Spark, TipRanks’ AI Analyst, ZYME is a Neutral.

The score is held back mainly by weak profitability and negative operating cash flow, with additional pressure from bearish/oversold technical signals. Offsetting these, the latest earnings call was meaningfully constructive—highlighting milestone-driven revenue growth, promising clinical updates, and a multi-year cash runway—supporting a more neutral overall outcome.

To see Spark’s full report on ZYME stock, click here.

More about Zymeworks

Zymeworks Inc. is a Vancouver-based biotechnology company that manages a portfolio of licensed healthcare assets while developing a diverse pipeline of novel, multifunctional biotherapeutics. The company focuses on antibody-drug conjugates, bispecific and trispecific biologics, and other targeted therapies aimed at solid tumors and inflammatory diseases, with a business model that blends partnered programs and wholly owned R&D assets to generate royalties, milestones, and long-term product value.

Average Trading Volume: 1,207,238

Technical Sentiment Signal: Buy

Current Market Cap: $1.74B

For detailed information about ZYME stock, go to TipRanks’ Stock Analysis page.