Upstream Bio, Inc. ((UPB)) announced an update on their ongoing clinical study.
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Upstream Bio, Inc. (UPB) is conducting a Phase 2b study titled A Phase 2b Randomized, Double-blind, Placebo-controlled, Parallel-Group Study to Assess Efficacy and Safety of Verekitug (UPB-101) in Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD). The study aims to evaluate the efficacy and safety of the drug verekitug in treating moderate-to-severe COPD, a significant inflammatory lung disease affecting millions worldwide.
The study tests the intervention of verekitug (UPB-101), administered in two dosages (100 mg and 400 mg) alongside a placebo. This drug is designed to potentially alleviate symptoms and improve the quality of life for COPD patients.
The study is interventional, with participants randomly assigned to different treatment groups. It employs a parallel model and quadruple masking, meaning neither the participants nor the care providers, investigators, or outcomes assessors know which treatment is being administered. The primary purpose of the study is treatment-focused.
The study began on May 9, 2025, with primary completion expected by the end of 2026. The latest update was submitted on October 9, 2025, indicating ongoing recruitment and progress.
This clinical update could positively impact Upstream Bio’s stock performance by boosting investor confidence in the company’s pipeline. Successful results could position UPB-101 as a competitive treatment option in the COPD market, potentially affecting the dynamics among industry players.
The study is ongoing, and further details are available on the ClinicalTrials portal.