Taysha Gene Therapies, Inc. ( (TSHA) ) has released its Q2 earnings. Here is a breakdown of the information Taysha Gene Therapies, Inc. presented to its investors.
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Taysha Gene Therapies, Inc. is a clinical-stage biotechnology company specializing in adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system, with a focus on developing transformative medicines for conditions like Rett syndrome.
In its latest earnings report, Taysha Gene Therapies announced significant advancements in its TSHA-102 development program for Rett syndrome, including the commencement of site activation for the REVEAL pivotal trial. The company also reported financial results for the second quarter of 2025, highlighting a strengthened balance sheet due to a successful public follow-on offering.
Key financial metrics revealed an increase in research and development expenses to $20.1 million, driven by clinical trial activities and manufacturing initiatives. General and administrative expenses also rose to $8.6 million. Despite these increases, the company secured $230 million from a public offering, extending its cash runway into 2028. The REVEAL trial, which showed promising results in earlier phases, is set to begin patient enrollment in Q4 2025.
The REVEAL pivotal trial is designed as a single-arm, open-label study focusing on females aged 6 to under 22 years with Rett syndrome. The trial aims to assess the efficacy of TSHA-102, which has shown a 100% response rate in earlier trials. The company plans to report new clinical data supporting the therapeutic impact of TSHA-102 by the end of the year.
Looking ahead, Taysha Gene Therapies remains optimistic about advancing TSHA-102 through regulatory pathways, with ongoing dialogues with the FDA and Health Canada. The company is poised to address the unmet medical needs of Rett syndrome patients, leveraging its strengthened financial position and promising clinical data.