Sophia Genetics Sa ((SOPH)) has held its Q3 earnings call. Read on for the main highlights of the call.
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SOPHiA GENETICS Reports Strong Q3 Performance Amid Challenges
The recent earnings call for SOPHiA GENETICS reflected a robust performance, marked by significant revenue growth and strategic expansions. Despite facing challenges such as operating losses and cash burn, the company’s innovative approaches and global partnerships paint a promising picture for the future.
Accelerated Revenue Growth
SOPHiA GENETICS reported a 23% year-over-year revenue increase in Q3, raising its 2025 revenue guidance to between $75 million and $77 million. This growth underscores the company’s strong market position and its ability to capitalize on emerging opportunities.
Strong Customer Acquisition
The company successfully signed 31 new customers in Q3, bringing the total for 2025 to 94, surpassing the 92 customers signed throughout 2024. This achievement highlights SOPHiA GENETICS’ effective customer acquisition strategies and its growing market presence.
U.S. Market Expansion
The U.S. market proved particularly fruitful, with a 30% year-over-year revenue increase. Notable new customers include Geisinger Health System and Baylor Scott & White Health, showcasing the company’s expanding footprint in a key market.
Global Reach and Partnerships
SOPHiA GENETICS expanded its global reach with new partnerships in Japan and the U.S. for liquid biopsy applications. A significant collaboration with AstraZeneca further enhances its global deployment capabilities.
Innovation and AI Development
The introduction of SOPHiA DDM Digital Twins, an AI-powered research tool for oncologists, marks a significant step in innovation. The company continues to expand its AI capabilities, reinforcing its position as a leader in technological advancements.
Healthy Financial Metrics
The company’s financial health remains strong, with a gross margin of 73.1% and a 13% improvement in adjusted EBITDA year-over-year, excluding Swiss social charges. These metrics reflect SOPHiA GENETICS’ operational efficiency and financial discipline.
Operating Loss and Cash Burn
Despite the positive metrics, SOPHiA GENETICS reported an operating loss of $17.9 million for Q3, with a 36.5% year-over-year increase in total cash burn, reaching $13.1 million. These figures highlight the financial challenges the company faces as it continues to invest in growth.
Challenges in Latin America
The company continues to experience softness in the Latin American market. However, recent booking momentum provides confidence in future growth prospects in the region.
Legal and Currency Challenges
Increased legal expenses due to a patent lawsuit and adverse foreign exchange movements have impacted operating expenses, presenting additional challenges for SOPHiA GENETICS.
Forward-Looking Guidance
SOPHiA GENETICS remains optimistic about its future, with a raised revenue guidance for 2025 and a focus on optimizing costs. The company aims to achieve adjusted EBITDA breakeven by the end of 2026, despite challenges such as Swiss social taxes and currency impacts.
In summary, SOPHiA GENETICS’ earnings call highlighted a strong performance with significant revenue growth and strategic expansions. While challenges persist, the company’s innovation and global partnerships provide a positive outlook for the future.

