Medtronic ((MDT)) announced an update on their ongoing clinical study.
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The CORE study, officially titled ‘Conducted AF-Response Study,’ aimed to evaluate the effectiveness of the Conducted AF-Response Algorithm (CAFR) in patients with heart failure and atrial fibrillation. Sponsored by Medtronic, this study was significant as it sought to enhance cardiac resynchronization therapy by increasing biventricular pacing during atrial fibrillation episodes, potentially improving patient outcomes.
The intervention tested was the Conducted AF-Response Algorithm (CAFR), a device-based algorithm designed to optimize biventricular stimulation in patients with atrial fibrillation. The study compared the effects of the CAFR being turned on versus off.
This interventional study was randomized with a parallel assignment model and single masking. The primary purpose was treatment-focused, aiming to assess the CAFR’s impact on heart rate and pacing efficiency.
The study began in December 2003, with its primary completion date not specified. The last update was submitted on June 30, 2025, indicating ongoing data collection or analysis.
While the study was terminated, its findings could influence Medtronic’s market position by informing future product development. Investors should consider the potential for innovation in cardiac therapies and the competitive landscape as Medtronic continues to explore advanced solutions.
The study is currently updated, and further details can be accessed on the ClinicalTrials portal.