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HUTCHMED’s Savolitinib Combo Shows Phase III Success in EGFR-Mutated Lung Cancer

Story Highlights
  • HUTCHMED’s savolitinib plus osimertinib combo outperformed chemotherapy in a Phase III SACHI trial for advanced EGFR-mutated NSCLC with MET amplification.
  • The strong efficacy and tolerable safety data supported Chinese approval of the all-oral regimen, bolstering HUTCHMED’s precision oncology position in MET-driven lung cancer.
  • Looking for the best stocks to buy? Follow the recommendations of top-performing analysts.
HUTCHMED’s Savolitinib Combo Shows Phase III Success in EGFR-Mutated Lung Cancer

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HUTCHMED (China) ( (HK:0013) ) just unveiled an update.

HUTCHMED highlighted the publication in The Lancet of Phase III SACHI trial results, which show that combining its MET inhibitor savolitinib (ORPATHYS®) with AstraZeneca’s osimertinib (TAGRISSO®) significantly improves progression-free survival and response rates versus chemotherapy in patients with advanced EGFR-mutated non-small cell lung cancer who develop MET amplification after prior EGFR-TKI treatment. The data underpin the June 2025 regulatory approval in China for the all-oral savolitinib–osimertinib regimen, reinforcing HUTCHMED’s position in precision oncology and expanding treatment options for a difficult-to-treat subset of lung cancer patients, with a tolerable safety profile and potential to further entrench the company’s role in MET-targeted therapy alongside AstraZeneca.

The most recent analyst rating on (HK:0013) stock is a Hold with a HK$23.00 price target. To see the full list of analyst forecasts on HUTCHMED (China) stock, see the HK:0013 Stock Forecast page.

More about HUTCHMED (China)

HUTCHMED (China) Limited is a biopharmaceutical company focused on the discovery, development and commercialization of targeted therapies, including the MET tyrosine kinase inhibitor savolitinib (marketed in China as ORPATHYS®), for patients with advanced solid tumors such as non-small cell lung cancer. It operates in partnership with AstraZeneca, which co-develops and commercializes savolitinib in China and is targeting patient populations with defined genetic drivers, including EGFR mutations and MET aberrations.

Average Trading Volume: 5,055,888

Technical Sentiment Signal: Strong Sell

Current Market Cap: HK$20.27B

For an in-depth examination of 0013 stock, go to TipRanks’ Overview page.

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