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Heron Therapeutics Reports Strong Preliminary Q4 2025 Revenue

Story Highlights
  • Heron posted preliminary Q4 2025 revenue of $40.5 million and full-year revenue of $154.9 million.
  • ZYNRELEF led portfolio growth with about 35% Q4 sequential revenue increase, signaling strong acute care momentum.
  • Looking for the best stocks to buy? Follow the recommendations of top-performing analysts.
Heron Therapeutics Reports Strong Preliminary Q4 2025 Revenue

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Heron Therapeutics ( (HRTX) ) has shared an announcement.

On January 9, 2026, Heron Therapeutics reported preliminary, unaudited net revenue of approximately $40.5 million for the fourth quarter ended December 31, 2025, and about $154.9 million for full-year 2025, underscoring continued momentum across its acute care and oncology supportive care portfolio. Within Q4, CINVANTI remained the largest revenue contributor at roughly $22.9 million, while ZYNRELEF generated about $12.5 million and delivered the strongest quarter-over-quarter growth in the portfolio, rising around 35% versus the third quarter, with APONVIE and SUSTOL contributing approximately $3.8 million and $1.3 million, respectively; the solid top-line performance and particularly strong uptake of ZYNRELEF highlight progress in Heron’s acute care franchise and suggest strengthening commercial execution heading into the company’s final audited results.

The most recent analyst rating on (HRTX) stock is a Buy with a $6.00 price target. To see the full list of analyst forecasts on Heron Therapeutics stock, see the HRTX Stock Forecast page.

Spark’s Take on HRTX Stock

According to Spark, TipRanks’ AI Analyst, HRTX is a Neutral.

Heron Therapeutics faces significant financial challenges, including high leverage and negative profitability, which weigh heavily on its overall stock score. While there are positive developments in product growth and strategic initiatives, these are offset by valuation concerns and technical indicators suggesting potential short-term volatility. The recent board appointment is a positive step but has a limited impact on the overall score.

To see Spark’s full report on HRTX stock, click here.

More about Heron Therapeutics

Heron Therapeutics, Inc., based in Cary, N.C., is a commercial-stage biotechnology company focused on developing and commercializing therapeutics that improve medical care for acute care and oncology patients. Its portfolio includes ZYNRELEF for postoperative pain, APONVIE and CINVANTI for prevention of chemotherapy- and surgery-related nausea and vomiting, and SUSTOL for chemotherapy-induced nausea and vomiting, leveraging proprietary drug delivery technologies to advance standards of care in these segments.

Average Trading Volume: 1,887,321

Technical Sentiment Signal: Sell

Current Market Cap: $231M

Learn more about HRTX stock on TipRanks’ Stock Analysis page.

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