Cellectis S.A. ((CLLS)) has held its Q2 earnings call. Read on for the main highlights of the call.
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Cellectis S.A.’s recent earnings call painted a picture of both progress and challenges, with significant advancements in clinical trials and strategic partnerships, particularly with AstraZeneca, contributing to a positive outlook. However, the company faces hurdles, including ongoing arbitration with Servier and a decrease in cash reserves, which temper the overall sentiment.
Initiation of Pivotal Phase II Trial for Lasme-cel
Cellectis is gearing up for a pivotal Phase II trial for lasme-cel, also known as UCART22, targeting relapsed or refractory acute lymphoblastic leukemia. This trial is set to commence in the second half of 2025, marking a significant milestone in their clinical development efforts.
Successful End of Phase I Discussions
The company successfully concluded Phase I discussions with both the FDA and EMA, receiving valuable feedback that paves the way for further clinical trials. This achievement underscores Cellectis’ commitment to advancing its therapeutic pipeline.
Partnership Progress with AstraZeneca
Cellectis continues to make strides under its Joint Research and Collaboration Agreement with AstraZeneca. The partnership focuses on three cell and gene therapy programs, highlighting the company’s strategic collaborations to enhance its research and development capabilities.
Financial Stability
Despite a decrease in cash reserves, Cellectis maintains financial stability with $230 million in cash, cash equivalents, and fixed-term deposits as of June 30, 2025. This financial position is expected to support operations into the second half of 2027.
Appointment of New Board Member
The appointment of Mr. André Muller to the Board of Directors brings a wealth of experience to Cellectis, strengthening its leadership team as the company navigates its growth trajectory.
Servier Arbitration Uncertainty
Cellectis is currently in arbitration with Servier over the cessation of development for licensed CD19 products. The outcome of this arbitration, expected by December 15, 2025, could have significant financial implications for the company.
Decrease in Cash Position
The company’s cash position saw a decline of $33.2 million from the previous year-end, attributed to operational expenses and cash payments. This decrease highlights the financial challenges Cellectis faces despite its stable outlook.
Forward-Looking Guidance
Looking ahead, Cellectis plans to initiate the pivotal Phase II trial for lasme-cel by the end of the year, with clinical trial sites opening for recruitment. The company is also preparing to present additional data at the ASH Annual Conference in Q4. The ongoing partnership with AstraZeneca remains a focal point, with continued research in cell and gene therapy programs. Financially, Cellectis is poised to sustain operations into H2 2027, though the pending arbitration with Servier could alter this trajectory. An Investors R&D Day is scheduled for October 16, 2025, to discuss future strategies and present detailed clinical data.
In conclusion, Cellectis S.A.’s earnings call reflects a balanced sentiment, with notable progress in clinical trials and partnerships offset by financial challenges and legal uncertainties. The company’s strategic initiatives and leadership enhancements position it well for future growth, though careful navigation of its financial and legal landscapes remains crucial.