Bolt Biotherapeutics, Inc. ((BOLT)) announced an update on their ongoing clinical study.
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In a promising development for cancer treatment, Bolt Biotherapeutics, Inc. (BOLT) is conducting a groundbreaking study titled ‘A Phase 1/2, First-in-Human, Dose Escalation and Expansion Study of BDC-4182 as a Single Agent in Patients With Advanced Gastric and Gastroesophageal Cancer.’ The study aims to evaluate the safety and efficacy of BDC-4182, a novel drug designed to treat advanced gastric and gastroesophageal cancers, marking a significant step in cancer therapeutics.
The intervention being tested is BDC-4182, an immune-stimulating antibody conjugate (ISAC). This drug is a combination of an anti-claudin 18.2 monoclonal antibody and a TLR 7/8 dual agonist, intended to enhance the immune response against cancer cells.
The study follows an interventional design with a non-randomized, sequential intervention model. It is focused on treatment, with no masking involved, allowing researchers to directly observe the effects of BDC-4182 on participants.
The study began on April 4, 2025, with the latest update submitted on August 28, 2025. These dates are crucial as they indicate the study’s progression and the timeliness of the data being collected.
This clinical study update could potentially impact BOLT’s stock performance positively, as successful results may boost investor confidence and position the company as a leader in cancer treatment innovation. The competitive landscape in oncology is intense, and breakthroughs like this can significantly influence market dynamics.
The study is currently recruiting, and further details can be accessed on the ClinicalTrials portal.