AstraZeneca ((AZN)), AstraZeneca plc ((GB:AZN)), AstraZeneca ((DE:ZEGA)), AstraZeneca plc US ((AZNCF)) announced an update on their ongoing clinical study.
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AstraZeneca is currently conducting a Phase III clinical trial titled A Randomised, Open-Label, Phase III Study of Saruparib (AZD5305) Plus Camizestrant Compared With Physician’s Choice CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant for the First-Line Treatment of Patients With BRCA1, BRCA2, or PALB2 Mutations and Hormone Receptor Positive, HER2-Negative Advanced Breast Cancer (EvoPAR-Breast01). The study aims to evaluate the efficacy of the combination of saruparib and camizestrant in treating advanced breast cancer patients with specific genetic mutations.
The interventions being tested include saruparib, a PARP1 inhibitor, and camizestrant, a next-generation SERD. These drugs are designed to target specific pathways in cancer cells, potentially offering more effective treatment options for patients with advanced breast cancer.
The study is designed as a randomized, open-label trial with a parallel intervention model. Participants are randomly assigned to one of three groups, with the primary purpose of treatment. The study does not employ masking, allowing for a clear comparison of treatment effects.
The trial began on August 1, 2024, with the primary completion and estimated study completion dates yet to be announced. The most recent update to the study was submitted on July 22, 2025, indicating ongoing progress.
This clinical study update could have significant market implications for AstraZeneca, potentially boosting investor confidence and stock performance if the results demonstrate positive outcomes. The study’s focus on advanced breast cancer treatment places AstraZeneca in a competitive position within the oncology market, particularly against other companies developing similar therapies.
The study is ongoing, with further details available on the ClinicalTrials portal.