AstraZeneca ((AZN)), Parexel International ((PRXL)), AstraZeneca plc ((GB:AZN)), AstraZeneca plc US ((AZNCF)), AstraZeneca ((DE:ZEGA)) announced an update on their ongoing clinical study.
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AstraZeneca, in collaboration with Parexel, is conducting a Phase II study titled ‘GEMINI-PeriOp GC’ to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-tumor activity of novel agents or combinations as perioperative treatment in patients with locally advanced resectable gastroesophageal adenocarcinoma. This study is significant as it aims to explore new treatment avenues for a challenging cancer type.
The interventions being tested include combinations of drugs such as AZD0901, Rilvegostomig, Trastuzumab Deruxtecan (T-DXd), Capecitabine, 5-Fluorouracil (5-FU), and FLOT chemotherapy. These drugs are administered either as intravenous infusions or orally, aiming to enhance treatment efficacy during the pre- and post-surgery periods.
The study design is interventional with a non-randomized, parallel assignment model. There is no masking involved, and the primary purpose is treatment. This straightforward design allows for the assessment of multiple drug combinations across different sub-studies.
The study began on July 17, 2025, with the latest update provided on July 29, 2025. These dates are crucial as they mark the commencement and the most recent progress in the study, indicating active recruitment and ongoing data collection.
Market implications of this study could be significant for AstraZeneca and its collaborators. Successful outcomes may boost investor confidence and positively impact stock performance. The study’s progress is also a critical indicator for competitors and the broader pharmaceutical industry, as it may set new benchmarks in cancer treatment.
The study is currently recruiting, and further details can be accessed on the ClinicalTrials portal.