AstraZeneca ((AZN)), AstraZeneca plc ((GB:AZN)), AstraZeneca ((DE:ZEGA)), AstraZeneca plc US ((AZNCF)) announced an update on their ongoing clinical study.
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The DESTINY-Endometrial01 study, officially titled ‘DESTINY-Endometrial01: An Open-Label, Sponsor-Blinded, Randomized, Controlled, Multicenter, Phase III Study of Trastuzumab Deruxtecan (T-DXd) Plus Rilvegostomig or Pembrolizumab vs Chemotherapy Plus Pembrolizumab as First-Line Therapy of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR), Primary Advanced or Recurrent Endometrial Cancer,’ aims to evaluate the efficacy of new treatment combinations for advanced endometrial cancer. The study’s key objective is to assess progression-free survival in patients with HER2-expressing, mismatch repair proficient endometrial cancer, providing significant insights into potential first-line therapies.
The study tests two experimental interventions: Trastuzumab Deruxtecan (T-DXd) combined with Rilvegostomig or Pembrolizumab, compared against a standard chemotherapy regimen of Carboplatin and Paclitaxel combined with Pembrolizumab. These treatments aim to improve patient outcomes by targeting specific cancer markers.
Designed as a randomized, open-label, sponsor-blinded Phase III trial, the study employs a parallel intervention model. Participants are randomly assigned to one of three treatment arms, with the primary purpose being treatment efficacy. The open-label design allows for direct observation of treatment effects, while sponsor-blinding ensures unbiased data analysis.
The study began on March 27, 2025, with the last update submitted on July 17, 2025. These dates mark the study’s progress and ensure transparency in its development, although the primary completion and estimated completion dates are yet to be announced.
This clinical update may influence AstraZeneca’s stock performance positively, as successful outcomes could enhance its oncology portfolio. Investors might view this as a competitive edge in the pharmaceutical industry, particularly against companies focusing on similar cancer therapies.
The DESTINY-Endometrial01 study is currently recruiting, with further details available on the ClinicalTrials portal.