Alx Oncology Holdings, Inc. ( (ALXO) ) has released its Q2 earnings. Here is a breakdown of the information Alx Oncology Holdings, Inc. presented to its investors.
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ALX Oncology Holdings, Inc. is a clinical-stage biotechnology company focused on developing innovative cancer therapies, with its lead candidate being evorpacept, which targets CD47 expression in tumors. In its second quarter 2025 earnings report, ALX Oncology highlighted significant advancements in its clinical programs, particularly the ASPEN-06 trial, which identified CD47 as a key biomarker for predicting response to evorpacept in HER2+ gastric cancer. The company also announced updates to its ASPEN-Breast trial design and the initiation of a Phase 1 trial for ALX2004, an EGFR-targeted therapy.
Key financial metrics from the report include a reduction in research and development expenses, which contributed to a decreased net loss compared to the previous year. The company reported cash, cash equivalents, and investments totaling $83.5 million, extending its cash runway into the first quarter of 2027. Strategic decisions, such as pausing the ASPEN-CRC study to focus on breast cancer, were made to optimize resources and extend financial stability.
The ASPEN-06 trial results showed a higher objective response rate in CD47-high gastric cancer patients treated with evorpacept, supporting its potential as a targeted therapy. The ASPEN-Breast trial will now evaluate both CD47-high and low patients, with interim data expected in Q3 2026. Additionally, the ALX2004 Phase 1 trial aims to address EGFR-expressing solid tumors, with patient dosing anticipated to begin in August 2025.
Looking ahead, ALX Oncology is poised to achieve multiple data milestones across its pipeline, supported by its extended cash runway. The company remains committed to advancing its clinical programs and leveraging its biomarker-driven strategies to enhance cancer treatment outcomes.