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Alnylam’s ALN-HTT02 Study: A Promising Step in Huntington’s Disease Treatment

Alnylam’s ALN-HTT02 Study: A Promising Step in Huntington’s Disease Treatment

Alnylam Pharmaceuticals ((ALNY)) announced an update on their ongoing clinical study.

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Study Overview: Alnylam Pharmaceuticals is conducting a study titled A Randomized, Double-blind, Placebo-controlled Study, to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally Administered Single Ascending Doses of ALN-HTT02 in Adult Patients With Huntington’s Disease. The study aims to assess the safety and effectiveness of ALN-HTT02 in treating Huntington’s Disease, a significant step in addressing this debilitating condition.

Intervention/Treatment: The study tests ALN-HTT02, an experimental drug administered intrathecally, designed to evaluate its safety and pharmacological effects in patients with Huntington’s Disease.

Study Design: This Phase 1 trial is interventional, utilizing a randomized, parallel assignment model. It employs triple masking, meaning the participant, care provider, and investigator are unaware of the treatment allocation. The primary goal is treatment-focused.

Study Timeline: The study began on October 14, 2024, with a primary completion date yet to be announced. The latest update was submitted on July 15, 2025, indicating ongoing recruitment and progress.

Market Implications: The progress of this study could significantly impact Alnylam Pharmaceuticals’ stock, as positive results may enhance investor confidence and market position. The study’s outcome could also influence the competitive landscape in the biopharmaceutical industry, particularly in treatments for neurodegenerative diseases.

The study is currently ongoing, with further details available on the ClinicalTrials portal.

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