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An update from Allogene Therapeutics ( (ALLO) ) is now available.
On August 1, 2025, Allogene Therapeutics announced the selection of standard fludarabine and cyclophosphamide as the lymphodepletion regimen for its ALPHA3 study, following a Grade 5 adverse event linked to ALLO-647. The decision to close the arm testing FC plus ALLO-647 was made after consultation with the FDA and the DSMB due to severe viral infections attributed to immunosuppression from ALLO-647. The amended ALPHA3 trial will now proceed with two arms, comparing cema-cel after standard FC lymphodepletion to observation, with the next milestone being a futility analysis expected in the first half of 2026. The company will focus on advancing its AlloCAR T product candidates using the Dagger® Platform Technology, which aims to reduce the need for standard lymphodepletion.
The most recent analyst rating on (ALLO) stock is a Buy with a $14.00 price target. To see the full list of analyst forecasts on Allogene Therapeutics stock, see the ALLO Stock Forecast page.
Spark’s Take on ALLO Stock
According to Spark, TipRanks’ AI Analyst, ALLO is a Neutral.
The overall stock score reflects significant financial challenges, including declining revenues and persistent losses. While technical analysis and earnings call sentiment provide some hope for future progress, valuation concerns weigh heavily due to negative earnings and the absence of dividends. The company’s ability to navigate operational inefficiencies and improve financial stability will be crucial for future performance.
To see Spark’s full report on ALLO stock, click here.
More about Allogene Therapeutics
Allogene Therapeutics, Inc. operates in the biotechnology industry, focusing on developing allogeneic CAR T cell therapies for cancer treatment. The company is known for its innovative approaches in immuno-oncology, particularly through its AlloCAR T product candidates and proprietary Dagger® Platform Technology.
Average Trading Volume: 3,541,828
Technical Sentiment Signal: Sell
Current Market Cap: $269M
For an in-depth examination of ALLO stock, go to TipRanks’ Overview page.