Spyre Therapeutics ( (SYRE) ) is experiencing volatility. Read on for a possible explanation for the stock’s unusual movement.
Claim 70% Off TipRanks Premium
- Unlock hedge fund-level data and powerful investing tools for smarter, sharper decisions
- Stay ahead of the market with the latest news and analysis and maximize your portfolio's potential
Spyre Therapeutics shares moved higher as investors focused on the company’s faster-than-expected clinical enrollment and a clearer path toward key trial readouts. The company said it now expects six proof-of-concept data readouts in 2026 and has accelerated the start of SKYLINE Part A to the second quarter after strong patient recruitment. Spyre also reported a pro forma cash balance of $783 million, which it says should fund operations into 2028, and announced the hire of an experienced commercial leader to support potential late-stage development and future product launches. While the strong pipeline momentum and solid cash runway have driven bullish sentiment, some investors remain cautious about the company’s sizable losses and continued cash burn, contributing to recent short-term volatility in the stock.
More about Spyre Therapeutics
YTD Price Performance: -8.00%
Average Trading Volume: 914,848
Technical Sentiment Signal: Hold
Current Market Cap: $2.34B
For further insights into SYRE stock on TipRanks’ Stock Analysis page.
See more of today’s top stock gainers and losers.

