Silo Pharma initiates pharmacokinetic, tolerability study for SP-26

Silo Pharma (SILO) announced the initiation of a pharmacokinetic and tolerability study in partnership with its contract research organization, AmplifyBio. The study is designed to assess the pharmacokinetics of Silo’s dissolvable ketamine-based injectable implant, SP-26, in a minipig model. SP-26 is being developed as a self-administered, non-opioid therapeutic aimed at treating chronic pain and fibromyalgia. The non-GLP study, set to span three weeks, will investigate the absorption, distribution, metabolism, and excretion of extended-release ketamine hydrochloride implants. Two distinct polymer formulations will be tested at varying dose levels.