Seer announces publications highlighting studies on Proteograph Product Suite

Seer announced three publications highlighting studies led by Christopher Mason, Ph.D. that show how Seer‘s Proteograph Product Suite can uncover novel insights into plasma proteomic changes that occur during spaceflight. The studies further demonstrate the power of the Proteograph workflow to offer scientists a deeper understanding of physiological responses and biology that can advance the development of novel biomarkers and precision medicines across a wide range of research sectors. Published in Nature, the first two manuscripts, “The Space Omics and Medical Atlas: A comprehensive data resource and international biobank for astronauts,” and “A second space age,” highlight data and a sample repository for clinical, cellular, and multiomic profiles from multiple space missions, including SpaceX Inspiration, Polaris Dawn, Axiom-2, NASA Twins Study, and JAXA Cell-Free RNA Study. The first-of-its-kind data resource, which includes plasma proteomic data generated from Seer’s Proteograph workflow, offers the life sciences and aerospace communities information that could further be leveraged to study aerospace-associated physiological changes. The third manuscript, “Secretome profiling captures acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight,” was published in Nature Communications, describing a study led by Dr. Mason, along with Seer scientists. In the study, the researchers profiled the secretome from astronauts of the first all-civilian space flight mission, the SpaceX Inspiration4, using multiple methods, including proteomic profiling from plasma using Seer’s Proteograph workflow. Additionally, the scientists evaluated brain-associated changes in spaceflight mice and changes in the blood-brain barrier. While the authors reported acute changes in secretome profiles that recovered six months following the return to Earth, a majority of the plasma differentially abundant proteins were still altered six months after return. More specifically, the researchers noted significant alterations in proteins involved in coagulation and wound healing, antioxidation, and brain function. The study, identified a total of 23,164 peptides mapping to 2,992 unique protein groups, with an average of 2,104 proteins detected per sample. The three papers are part of a set of 44 space mission papers published in Nature journals today. These papers highlight the in-depth profiles from the missions, showcase the plans for upcoming missions to the moon and Mars, and provide additional information on the Proteograph data gathered.